\documentclass{letter}
\usepackage[top=0.5in, bottom=1in, right = 1in, left = 1in]{geometry}
\usepackage{hyperref}
\usepackage{graphicx}
\usepackage{wrapfig}
\usepackage[dvipsnames]{xcolor}
\usepackage{palatino}
\usepackage[T1]{fontenc}
\usepackage{tgadventor}
\usepackage{lipsum}
\signature{Prof. Big S. Hot}
% \address{\large \textbf{Iowa State University} \vspace{3pt} \\ \large \textbf{College } \\ \large \textbf{Veterinary medicine} \vspace{3pt} \\ \\ Ames, IA 50011}
% \date{}
\address{
\textcolor{BrickRed}{\textbf{College of Veterinary Medicine}} \\
\textbf{Department of Veterinary Microbiology and} \\
\textbf{Preventive Medicine} \\
\textbf{Ames, IA 50010-1134}}
\longindentation=40pt
\begin{document}
\begin{letter}
{
\centering \textbf{Re: topic of importance}
}
\hfill
\begin{wrapfigure}[1]{l}{0.50\linewidth}%{height=0.65\textheight}
\centering
%\includegraphics[width=0.65\textwidth]{asu_sese_logo.jpg}
%\includegraphics[width=0.50\textwidth]{ISULEFT.eps}
\includegraphics[width=0.50\textwidth]{ISU-letterhead-2tone.png}
\end{wrapfigure}
\opening{To Whom it May Concern,}
\medskip
\lipsum[1-3]
%\medskip
\closing{Sincerely,}
% Sincerely, \\ \\ \\
% Iddo Friedberg
\end{letter}
\end{document}
